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2Á¾ÀÇ °æÈ­¾×°ú È¥ÇÕµÈ calcium phosphate cementÀÇ À¯º¯ÇÐÀû ¼ºÁú¿¡ °üÇÑ ¿¬±¸

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Àå¼®¿ì ( Chang Seok-Woo ) - Çѱ¹°Ç¼³±â¼ú¿¬±¸¿ø
±ÇÈ£¹ü ( Kwon Ho-Beom ) - ¼º±Õ°ü´ëÇб³
¹è±¤½Ä ( Bae Kwang-Shik ) - ¼­¿ï´ëÇб³ Ä¡°ú´ëÇÐ Ä¡°úº¸Á¸Çб³½Ç
À¯Çö¹Ì ( Yoo Heyon-Mee ) - ¼º±Õ°ü´ëÇб³
¹Úµ¿¼º ( Park Dong-Sung ) - ¼º±Õ°ü´ëÇб³
¿Àż® ( Oh Tae-Seok ) - ¼º±Õ°ü´ëÇб³

Abstract

Calcium phosphate cement (CPC)´Â ¿ì¼öÇÑ »ýü ģȭ¼ºÀ» ¹ÙÅÁÀ¸·Î Ä¡°ú ¹× ÀÇ°ú ÂÊ¿¡¼­ ¼º°øÀûÀÎ bone substitute·Î »ç¿ëµÇ¾î ¿Ô´Ù. ±ä °æÈ­½Ã°£ ¹× washout tendency µî CPCÀÇ ´ÜÁ¡À» °³¼±Çϱâ À§ÇØ ´Ù¾çÇÑ Á¾·ùÀÇ °æÈ­¾× ¹× ÷°¡Á¦µî¿¡ ´ëÇÑ ¿¬±¸°¡ ÀÌ·ç¾îÁ³´Ù. ±×·¯³ª ÷°¡Á¦ÀÇ Á¾·ù¿¡ µû¸¥ CPC pasteÀÇ Á¡Åº¼ºÀ» Á¤·®ÀûÀ¸·Î ºñ±³ÇÑ ¿¬±¸´Â ¸¹Áö ¾Ê´Ù. ÀÌ ¿¬±¸¿¡¼­´Â 2% hydroxyprophyl methylcellulose (HPMC)¿Í 35% polyacrylic acid (PAA)ÀÇ µÎ °¡Áö °æÈ­¾×°ú È¥ÇÕµÈ CPCÀÇ À¯º¯ÇÐÀû ¼ºÁúÀ» °üÂûÇÏ°í ºñ±³ÇÏ°íÀÚ ÇÏ¿´´Ù. Dicalcium phosphate dihydrate (DCPD)¸¦ 2% HPMC ¹× 35% PAA¿Í °¢°¢ 1:1ÀÇ ºÐ¾×ºñ·Î 30ÃÊ°£ ¼¯Àº ÈÄ cone and plate geometry¸¦ °¡Áö´Â rheometer¸¦ »ç¿ëÇÏ¿© frequency sweep test¿Í time sweep test¸¦ ÅëÇØ shear storage modulus (G¡¯), shear loss modulus (G¡¯¡¯), ±×¸®°í complex viscosity (¥ç*)¸¦ ÃøÁ¤ÇÏ¿´´Ù. 2% HPMC±º°ú 35% PAA±ºÀÇ complex viscostiyÀÇ Â÷À̸¦ Mann-whitney test with Bonferroni¡¯s collectionÀ» »ç¿ëÇÏ¿© ºÐ¼®ÇÏ¿´´Ù. ½ÇÇè°á°ú 2% HPMC ¹× 35% PAA ±º ¸ðµÎ¿¡¼­ shear thinning°ú yield behaviorµî pseudoplastic property¸¦ º¸¿´À¸¸ç complex viscosity´Â HPMC ±º¿¡¼­ PAA ±ºº¸´Ù Åë°èÀûÀ¸·Î À¯ÀǼº ÀÖ°Ô ³ô¾Ò´Ù. (p<0.05)

Calcium phosphate cement (CPC) has been used as bone substitute successfully due to good biocompatibility and osteoconductivity. One of the important mechanical characteristics of CPC is flowablility, which can be evaluated by measuring rheological parameters. However, there have been few studies that measured rheological properties of CPC. The purpose of this study was to evaluate the rheological properties of CPC paste mixed with 2 kinds of setting solutions, 2% hydroxyprophyl methylcellulose (HPMC) and 35% polyacrylic acid (PAA). The CPC used was dicalcium phosphate dihydrate (DCPD). Rheological properties of CPC paste were measured using rheometer. The statistical analysis was carried out with Mann-whitney test with Bonferronis collection. CPC with both setting solutions showed shear thinning behavior. CPC with 2% HPMC showed signigicantly higher complex viscosity than CPC with 35% PAA(p<0.05).

Å°¿öµå

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calcium phosphate cement;hydroxyprophyl methylcellulose;polyacrylic acid;rheological characteristics

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